I decided to write a post on this today because a patient asked me about it, and it seems to be gaining more and more popularity.
The clinical trials showed the average weight loss was 14.4% body weight with the high dose and 6.7% body weight for the lower dose formula. A different study showed that 48% of study patients lost >10% of their body weight with the high dose.
So, how's it work? Qnexa combines phentermine and topiramate into one extended-release, once a day capsule. Phentermine is a popular weight loss medication, that works by suppressing appetite and stimulating your body's metabolism. Topiramate is classically used as an anti-seizure medication, but in Qnexa, it is being used in combination with the phentermine to alter the way that food tastes. The food will not taste bad, just different.
So, overall, I would never advise a medication over good old diet and exercise, BUT...if you really have tried everything and are having a difficult time losing weight "on you own" this may be a great option for you!
When the medication gets final FDA approval, I will be sure to post..:)